Family Assignments

Domains Proteins SCOP Link Families
28 28 SCOP 88854 Protein kinases, catalytic subunit
27 27 SCOP 52592 G proteins
17 15 SCOP 81269 Extended AAA-ATPase domain
13 10 SCOP 81268 Tandem AAA-ATPase domain
10 5 SCOP 53068 Actin/HSP70
9 9 SCOP 56251 Proteasome subunits
8 8 SCOP 54496 UBC-related
7 7 SCOP 47114 Nucleosome core histones
6 6 SCOP 50136 Alcohol dehydrogenase-like, N-terminal domain
6 6 SCOP 51431 Aldo-keto reductases (NADP)
6 6 SCOP 51736 Alcohol dehydrogenase-like, C-terminal domain
6 6 SCOP 102609 Glycolipid 2-alpha-mannosyltransferase
5 5 SCOP 50282 Cold shock DNA-binding domain-like
5 5 SCOP 50979 WD40-repeat
5 5 SCOP 51605 Enolase
5 5 SCOP 51800 Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain
5 5 SCOP 52541 Nucleotide and nucleoside kinases
5 5 SCOP 53402 Cystathionine synthase-like
5 5 SCOP 54827 Enolase N-terminal domain-like
5 5 SCOP 55682 Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain
4 4 SCOP 48020 DNA polymerase III clamp loader subunits, C-terminal domain
4 4 SCOP 50448 Elongation factors
4 4 SCOP 51446 Amylase, catalytic domain
4 4 SCOP 52325 DJ-1/PfpI
4 4 SCOP 52375 Class I aminoacyl-tRNA synthetases (RS), catalytic domain
4 4 SCOP 52403 N-type ATP pyrophosphatases
4 4 SCOP 52641 Motor proteins
4 3 SCOP 52686 ABC transporter ATPase domain-like
4 4 SCOP 52744 Subtilases
4 4 SCOP 53272 Phosphoribosyltransferases (PRTases)
4 4 SCOP 53687 Tryptophan synthase beta subunit-like PLP-dependent enzymes
4 4 SCOP 53721 ALDH-like
4 4 SCOP 54431 NTF2-like
4 2 SCOP 54981 EF-G/eEF-2 domains III and V
4 4 SCOP 55921 Creatinase/aminopeptidase
4 4 SCOP 88724 Pyruvate oxidase and decarboxylase Pyr module
4 4 SCOP 100921 Heat shock protein 70kD (HSP70), peptide-binding domain
4 4 SCOP 103507 Mitochondrial carrier
3 3 SCOP 47502 Calmodulin-like
3 3 SCOP 47662 t-snare proteins
3 3 SCOP 48246 Protein prenyltransferases
3 3 SCOP 48453 Tetratricopeptide repeat (TPR)
3 3 SCOP 48558 L-aspartase/fumarase
3 3 SCOP 50646 Pepsin-like
3 3 SCOP 50892 Cyclophilin (peptidylprolyl isomerase)
3 3 SCOP 51868 6-phosphogluconate dehydrogenase-like, N-terminal domain
3 3 SCOP 52318 Class I glutamine amidotransferases (GAT)
3 3 SCOP 52901 Glutathione peroxidase-like
3 2 SCOP 53083 Hexokinase
3 3 SCOP 53255 Cofactor-dependent phosphoglycerate mutase
3 3 SCOP 53384 AAT-like
3 3 SCOP 53417 GABA-aminotransferase-like
3 1 SCOP 53739 Phosphoglucomutase, first 3 domains
3 3 SCOP 54212 Translational machinery components
3 3 SCOP 54237 Ubiquitin-related
3 3 SCOP 55730 N-acetyl transferase, NAT
3 1 SCOP 55974 S-adenosylmethionine synthetase
3 3 SCOP 56236 Class II glutamine amidotransferases
3 3 SCOP 56310 Protein serine/threonine phosphatase
3 3 SCOP 56802 Acetyl-CoA synthetase-like
3 3 SCOP 88749 Pyruvate oxidase and decarboxylase PP module
3 3 SCOP 100908 MIF4G domain-like
2 2 SCOP 46690 Homeodomain
2 1 SCOP 46827 Linker histone H1/H5
2 2 SCOP 47096 HMG-box
2 2 SCOP 48180 Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain
2 2 SCOP 48257 Citrate synthase
2 2 SCOP 48404 Ankyrin repeat
2 2 SCOP 48446 14-3-3 protein
2 2 SCOP 48577 Isoprenyl diphosphate synthases
2 1 SCOP 49494 HSP40/DnaJ peptide-binding domain
2 2 SCOP 50045 SH3-domain
2 2 SCOP 50307 DNA ligase/mRNA capping enzyme postcatalytic domain
2 2 SCOP 50785 Transcription factor IIA (TFIIA), beta-barrel domain
2 2 SCOP 50801 Pyruvate kinase beta-barrel domain
2 2 SCOP 51231 Biotinyl/lipoyl-carrier proteins and domains
2 2 SCOP 51534 Type II chitinase
2 2 SCOP 51622 Pyruvate kinase
2 1 SCOP 51751 Tyrosine-dependent oxidoreductases
2 2 SCOP 51848 LDH N-terminal domain-like
2 2 SCOP 52103 Crotonase-like
2 2 SCOP 52475 Pyruvate oxidase and decarboxylase, middle domain
2 2 SCOP 52491 Tubulin, GTPase domain
2 2 SCOP 52652 Nitrogenase iron protein-like
2 2 SCOP 52800 Dual specificity phosphatase-like
2 2 SCOP 52936 Pyruvate kinase, C-terminal domain
2 2 SCOP 53258 Histidine acid phosphatase
2 2 SCOP 53296 Phosphoribosylpyrophosphate synthetase-like
2 2 SCOP 53614 Ribokinase-like
2 2 SCOP 53620 Thiamin biosynthesis kinases
2 2 SCOP 53660 Dimeric isocitrate & isopropylmalate dehydrogenases
2 1 SCOP 53785 Phosphofructokinase
2 2 SCOP 54193 L15e
2 1 SCOP 54207 Hexose-1-phosphate uridylyltransferase
2 2 SCOP 54535 FKBP immunophilin/proline isomerase
2 2 SCOP 55283 Ribosomal protein L5
2 2 SCOP 55299 YjgF/L-PSP
2 2 SCOP 55363 Homoserine dehydrogenase-like
2 2 SCOP 55376 Glucose 6-phosphate dehydrogenase-like
2 1 SCOP 55748 N-myristoyl transferase, NMT
2 2 SCOP 56048 Ribosomal protein S8
2 2 SCOP 56656 Inositol monophosphatase/fructose-1,6-bisphosphatase-like
2 2 SCOP 56895 Aquaporin-like
2 2 SCOP 57799 Casein kinase II beta subunit
2 2 SCOP 57869 Metallothionein
2 2 SCOP 57960 Leucine zipper domain
2 2 SCOP 58039 SNARE fusion complex
2 1 SCOP 63412 MPP-like
2 2 SCOP 63971 Inosicase
2 2 SCOP 64198 AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC
2 2 SCOP 69557 Spermidine synthase
2 1 SCOP 69815 Tyrosyl-DNA phosphodiesterase TDP1
2 2 SCOP 74771 Clathrin adaptor core protein
2 2 SCOP 75521 Clathrin coat assembly domain
2 2 SCOP 75633 Cullin homology domain
2 1 SCOP 82424 Choline/Carnitine O-acyltransferase
2 2 SCOP 82515 PfkB-like kinase
2 2 SCOP 82540 Trehalose-6-phosphate synthase, OtsA
2 2 SCOP 82568 Ubiquitin carboxyl-terminal hydrolase, UCH
2 2 SCOP 89494 HMGL-like
2 2 SCOP 101490 Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain
2 2 SCOP 103492 Preprotein translocase SecY subunit
2 1 SCOP 109692 Vacuolar sorting protein domain
2 2 SCOP 110509 NLI interacting factor-like phosphatase
2 2 SCOP 111353 Ammonium transporter
2 1 SCOP 142678 Glycine dehydrogenase subunits (GDC-P)
2 2 SCOP 144001 Oxysterol-binding protein
1 1 SCOP 46549 Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain
1 1 SCOP 46676 Cytochrome bc1 domain
1 1 SCOP 46873 Heat-shock transcription factor
1 1 SCOP 46925 RNA polymerase subunit RPB10
1 1 SCOP 46939 CRAL/TRIO N-terminal domain
1 1 SCOP 47230 Phosphorelay protein-like
1 1 SCOP 47253 Ribonucleotide reductase-like
1 1 SCOP 47397 Transcription factor IIA (TFIIA), alpha-helical domain
1 1 SCOP 47460 HLH, helix-loop-helix DNA-binding domain
1 1 SCOP 47577 Calponin-homology domain, CH-domain
1 1 SCOP 47617 Glutathione S-transferase (GST), C-terminal domain
1 1 SCOP 47773 SAM (sterile alpha motif) domain
1 1 SCOP 47918 C-terminal domain of alpha and beta subunits of F1 ATP synthase
1 1 SCOP 47955 Cyclin
1 1 SCOP 48114 CCP-like
1 1 SCOP 48157 DNA repair glycosylase, 2 C-terminal domains
1 1 SCOP 48209 Glucoamylase
1 1 SCOP 48226 Class I alpha-1;2-mannosidase, catalytic domain
1 1 SCOP 48372 Armadillo repeat
1 1 SCOP 48426 Sec7 domain
1 1 SCOP 48440 Protein prenylyltransferase
1 1 SCOP 48465 ENTH domain
1 1 SCOP 49330 Cu,Zn superoxide dismutase-like
1 1 SCOP 49778 Phosphatidylethanolamine binding protein
1 1 SCOP 50194 Ribosomal protein L14
1 1 SCOP 50263 Single strand DNA-binding domain, SSB
1 1 SCOP 50461 Ribosomal protein L3
1 1 SCOP 50466 EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
1 1 SCOP 50616 N-terminal domain of alpha and beta subunits of F1 ATP synthase
1 1 SCOP 50708 Cdc48 N-terminal domain-like
1 1 SCOP 50764 Ran-binding domain
1 1 SCOP 51191 Type I phosphomannose isomerase
1 1 SCOP 51284 dUTPase-like
1 1 SCOP 51372 D-ribulose-5-phosphate 3-epimerase
1 1 SCOP 51381 Tryptophan biosynthesis enzymes
1 1 SCOP 51413 Inosine monophosphate dehydrogenase (IMPDH)
1 1 SCOP 51420 Alanine racemase-like, N-terminal domain
1 1 SCOP 51487 beta-glycanases
1 1 SCOP 51557 Adenosine/AMP deaminase
1 1 SCOP 51591 Class II FBP aldolase
1 1 SCOP 51599 Class I DAHP synthetase
1 1 SCOP 51691 NadC C-terminal domain-like
1 1 SCOP 51883 Aminoacid dehydrogenase-like, C-terminal domain
1 1 SCOP 51934 Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain
1 1 SCOP 52002 R1 subunit of ribonucleotide reductase, C-terminal domain
1 1 SCOP 52017 LeuD-like
1 1 SCOP 52022 Carbamoyl phosphate synthetase, small subunit N-terminal domain
1 1 SCOP 52052 Rna1p (RanGAP1), N-terminal domain
1 1 SCOP 52088 CRAL/TRIO domain
1 1 SCOP 52162 Ribosomal protein L13
1 1 SCOP 52314 Ribosomal protein S2
1 1 SCOP 52419 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
1 1 SCOP 52432 ETFP subunits
1 1 SCOP 52584 Phosphoribulokinase/pantothenate kinase
1 1 SCOP 52589 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain
1 1 SCOP 52670 RecA protein-like (ATPase-domain)
1 1 SCOP 52773 Histone deacetylase, HDAC
1 1 SCOP 52778 CAT-like
1 1 SCOP 52805 Higher-molecular-weight phosphotyrosine protein phosphatases
1 1 SCOP 52849 PDI-like
1 1 SCOP 52862 Glutathione S-transferase (GST), N-terminal domain
1 1 SCOP 52895 spliceosomal protein U5-15Kd
1 1 SCOP 52926 Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain
1 1 SCOP 52944 ATP synthase (F1-ATPase), gamma subunit
1 1 SCOP 52973 ITPase (Ham1)
1 1 SCOP 53037 Eukaryotic RPB5 N-terminal domain
1 1 SCOP 53057 beta-carbonic anhydrase, cab
1 1 SCOP 53099 Ribonuclease H
1 1 SCOP 53118 DnaQ-like 3'-5' exonuclease
1 1 SCOP 53143 ERF1/Dom34 middle domain-like
1 1 SCOP 53168 Purine and uridine phosphorylases
1 1 SCOP 53204 Bacterial dinuclear zinc exopeptidases
1 1 SCOP 53235 Tetrahydrofolate dehydrogenase/cyclohydrolase
1 1 SCOP 53342 Fibrillarin homologue
1 1 SCOP 53499 Serine carboxypeptidase-like
1 1 SCOP 53547 Carboxylesterase/thioesterase 1
1 1 SCOP 53591 Nucleoside hydrolase
1 1 SCOP 53629 Folylpolyglutamate synthetase
1 1 SCOP 53650 Alkaline phosphatase
1 1 SCOP 53672 Aspartate/ornithine carbamoyltransferase
1 1 SCOP 53698 double-SIS domain
1 1 SCOP 53701 Phosphoglucose isomerase, PGI
1 1 SCOP 53733 Aconitase iron-sulfur domain
1 1 SCOP 53749 Phosphoglycerate kinase
1 1 SCOP 53766 Oligosaccharide phosphorylase
1 1 SCOP 53791 Tetrapyrrole methylase
1 1 SCOP 53902 Thiolase-related
1 1 SCOP 54002 Papain-like
1 1 SCOP 54054 Adenain-like
1 1 SCOP 54229 Ribonuclease PH domain 1-like
1 1 SCOP 54253 GABARAP-like
1 1 SCOP 54586 Cdc48 domain 2-like
1 1 SCOP 54617 DNA-binding domain of Mlu1-box binding protein MBP1
1 1 SCOP 54632 CBS-domain pair
1 1 SCOP 54687 Ribosomal protein L10e
1 1 SCOP 54720 Fe,Mn superoxide dismutase (SOD), C-terminal domain
1 1 SCOP 54748 Ribosomal L11/L12e N-terminal domain
1 1 SCOP 54792 Eukaryotic type KH-domain (KH-domain type I)
1 1 SCOP 54811 GMP synthetase C-terminal dimerisation domain
1 1 SCOP 54815 Prokaryotic type KH domain (KH-domain type II)
1 1 SCOP 54929 Canonical RBD
1 1 SCOP 55009 HMA, heavy metal-associated domain
1 1 SCOP 55069 Peptide methionine sulfoxide reductase
1 1 SCOP 55160 eIF1-like
1 1 SCOP 55288 RPB5
1 1 SCOP 55294 RPB6
1 1 SCOP 55308 Tubulin, C-terminal domain
1 1 SCOP 55316 L30e/L7ae ribosomal proteins
1 1 SCOP 55323 ERF1/Dom34 C-terminal domain-like
1 1 SCOP 55327 PurM N-terminal domain-like
1 1 SCOP 55368 Dihydrodipicolinate reductase-like
1 1 SCOP 55419 Translation initiation factor eIF4e
1 1 SCOP 55456 SRF-like
1 1 SCOP 55482 N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1
1 1 SCOP 55505 Neurolysin-like
1 1 SCOP 55621 GTP cyclohydrolase I
1 1 SCOP 55725 Ran-binding protein mog1p
1 1 SCOP 55771 Profilin (actin-binding protein)
1 1 SCOP 55782 GAF domain
1 1 SCOP 55817 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain
1 1 SCOP 55879 DNA gyrase/MutL, N-terminal domain
1 1 SCOP 55910 Ribosome anti-association factor eIF6 (aIF6)
1 1 SCOP 55958 Phosphoglucomutase, C-terminal domain
1 1 SCOP 56020 The spindle assembly checkpoint protein mad2
1 1 SCOP 56043 PurM C-terminal domain-like
1 1 SCOP 56067 BC ATP-binding domain-like
1 1 SCOP 56092 ATP-dependent DNA ligase catalytic domain
1 1 SCOP 56100 mRNA capping enzyme
1 1 SCOP 56105 SAICAR synthase
1 1 SCOP 56108 Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta
1 1 SCOP 56307 5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain
1 1 SCOP 56328 Lactate & malate dehydrogenases, C-terminal domain
1 1 SCOP 56426 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
1 1 SCOP 56530 FAH
1 1 SCOP 56635 Heme-dependent catalases
1 1 SCOP 56691 T7 RNA polymerase
1 1 SCOP 56753 D-aminoacid aminotransferase-like PLP-dependent enzymes
1 1 SCOP 56816 Sec1/munc18-like (SM) proteins
1 1 SCOP 57784 Transcriptional factor domain
1 1 SCOP 57851 RING finger domain, C3HC4
1 1 SCOP 57904 FYVE, a phosphatidylinositol-3-phosphate binding domain
1 1 SCOP 63888 P-domain of calnexin/calreticulin
1 1 SCOP 63976 Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC)
1 1 SCOP 63984 Sir2 family of transcriptional regulators
1 1 SCOP 64154 YjeF N-terminal domain-like
1 1 SCOP 64311 RBP11/RpoL
1 1 SCOP 64372 3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB
1 1 SCOP 64490 RNA-polymerase beta-prime
1 1 SCOP 64511 Phosphoserine phosphatase
1 1 SCOP 69001 FAD-dependent thiol oxidase
1 1 SCOP 69044 RNA polymerase II subunit RBP4 (RpoF)
1 1 SCOP 69061 Arp2/3 complex 21 kDa subunit ARPC3
1 1 SCOP 69341 C-terminal domain of adenylylcyclase associated protein
1 1 SCOP 69565 Pyridoxal-dependent decarboxylase
1 1 SCOP 69646 Arp2/3 complex subunits
1 1 SCOP 69865 Argininosuccinate synthetase, C-terminal domain
1 1 SCOP 69892 Iron-containing alcohol dehydrogenase
1 1 SCOP 74789 Cullin repeat
1 1 SCOP 75038 TauD/TfdA-like
1 1 SCOP 75073 Hydantoinase (dihydropyrimidinase), catalytic domain
1 1 SCOP 75273 Glycogenin
1 1 SCOP 75305 Amidase signature (AS) enzymes
1 1 SCOP 75626 YebC-like
1 1 SCOP 81288 RhoGDI-like
1 1 SCOP 81495 Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor
1 1 SCOP 81523 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
1 1 SCOP 81605 PP2C-like
1 1 SCOP 81656 Meta-cation ATPase, catalytic domain P
1 1 SCOP 81664 Calcium ATPase, transmembrane domain M
1 1 SCOP 81843 Mannitol 2-dehydrogenase
1 1 SCOP 81992 DNA-binding domain from NDT80
1 1 SCOP 82062 BAH domain
1 1 SCOP 82191 Acireductone dioxygenase
1 1 SCOP 82388 Predicted hydrolases Cof
1 1 SCOP 82583 G domain-linked domain
1 1 SCOP 82636 MaoC-like
1 1 SCOP 88683 Eukaryotic ODC-like
1 1 SCOP 88704 Phosphoenolpyruvate mutase/Isocitrate lyase-like
1 1 SCOP 88741 Branched-chain alpha-keto acid dehydrogenase Pyr module
1 1 SCOP 88766 Branched-chain alpha-keto acid dehydrogenase PP module
1 1 SCOP 88799 N-terminal, heterodimerisation domain of RBP7 (RpoE)
1 1 SCOP 89125 Nop domain
1 1 SCOP 89249 Proprotein convertase P-domain
1 1 SCOP 89590 NADPH-dependent FMN reductase
1 1 SCOP 89724 Macro domain
1 1 SCOP 89746 Catalytic, N-terminal domain of histone methyltransferase Dot1l
1 1 SCOP 89800 Deoxycytidylate deaminase-like
1 1 SCOP 89958 MTH1187-like
1 1 SCOP 89976 Hypothetical protein Yml108w
1 1 SCOP 90097 Capz alpha-1 subunit
1 1 SCOP 90100 Capz beta-1 subunit
1 1 SCOP 101153 Mob1/phocein
1 1 SCOP 101279 N-terminal domain of adenylylcyclase associated protein, CAP
1 1 SCOP 101448 Formin homology 2 domain (FH2 domain)
1 1 SCOP 101836 Dcp1
1 1 SCOP 102406 MoCo carrier protein-like
1 1 SCOP 102463 Peptidyl-tRNA hydrolase II
1 1 SCOP 102492 CAF1-like ribonuclease
1 1 SCOP 102745 mRNA decapping enzyme DcpS C-terminal domain
1 1 SCOP 102928 NifU/IscU domain
1 1 SCOP 103026 Aminomethyltransferase folate-binding domain
1 1 SCOP 103112 Activator of Hsp90 ATPase, Aha1
1 1 SCOP 109975 RPR domain (SMART 00582 )
1 1 SCOP 110020 ERO1-like
1 1 SCOP 110112 Ctag/Cox11
1 1 SCOP 110289 Cell cycle arrest protein BUB3
1 1 SCOP 110702 Putative serine hydrolase Ydr428c
1 1 SCOP 110907 Monomeric nicotinate phosphoribosyltransferase N-terminal domain-like
1 1 SCOP 110910 Monomeric nicotinate phosphoribosyltransferase C-terminal domain
1 1 SCOP 110994 eIF-2-alpha, C-terminal domain
1 1 SCOP 111219 ArgJ-like
1 1 SCOP 116743 eIF2alpha middle domain-like
1 1 SCOP 116795 Rad21/Rec8-like
1 1 SCOP 117019 ATP-dependent DNA ligase DNA-binding domain
1 1 SCOP 117033 COX17-like
1 1 SCOP 117318 YML079-like
1 1 SCOP 117714 Hypothetical esterase YJL068C
1 1 SCOP 118076 TRAPP components
1 1 SCOP 140115 VPS28 N-terminal domain
1 1 SCOP 140118 VPS37 C-terminal domain-like
1 1 SCOP 140428 VPS28 C-terminal domain-like
1 1 SCOP 140719 CSE2-like
1 1 SCOP 140722 MED7 hinge region
1 1 SCOP 140851 Exocyst complex component
1 1 SCOP 140963 Indoleamine 2,3-dioxygenase-like
1 1 SCOP 140991 FtsH protease domain-like
1 1 SCOP 141368 UbiD middle domain-like
1 1 SCOP 142395 YKR049C-like
1 1 SCOP 142696 RibA-like
1 1 SCOP 143001 TIM44-like
1 1 SCOP 143027 Spc25-like
1 1 SCOP 143642 LplA-like
1 1 SCOP 143927 beta-CASP RNA-metabolising hydrolases
1 1 SCOP 144006 ORC1-binding domain
1 1 SCOP 144211 Nucleolar RNA-binding protein Nop10-like
1 1 SCOP 144218 CSL zinc finger
1 1 SCOP 158782 HAT/Suf repeat
1 1 SCOP 158886 AMPK-beta glycogen binding domain-like
1 1 SCOP 159513 EMG1/NEP1-like
1 1 SCOP 159623 Fumble-like
1 1 SCOP 159697 TRM1-like
1 1 SCOP 160220 AMPKBI-like
1 1 SCOP 160723 Ssp2 C-terminal domain-like

The following families have one or more weak hits: