Family Assignments

Domains Proteins SCOP Link Families
178 178 SCOP 88854 Protein kinases, catalytic subunit
147 147 SCOP 52592 G proteins
78 50 SCOP 53068 Actin/HSP70
60 47 SCOP 81269 Extended AAA-ATPase domain
43 30 SCOP 52686 ABC transporter ATPase domain-like
41 41 SCOP 56310 Protein serine/threonine phosphatase
28 22 SCOP 81268 Tandem AAA-ATPase domain
21 21 SCOP 52901 Glutathione peroxidase-like
19 19 SCOP 81605 PP2C-like
18 18 SCOP 56251 Proteasome subunits
18 18 SCOP 100921 Heat shock protein 70kD (HSP70), peptide-binding domain
17 17 SCOP 111348 Rap/Ran-GAP
16 16 SCOP 51446 Amylase, catalytic domain
14 14 SCOP 48367 Ras GEF
14 14 SCOP 54496 UBC-related
12 12 SCOP 50979 WD40-repeat
11 11 SCOP 52375 Class I aminoacyl-tRNA synthetases (RS), catalytic domain
11 11 SCOP 54002 Papain-like
11 11 SCOP 55682 Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain
10 10 SCOP 69892 Iron-containing alcohol dehydrogenase
10 10 SCOP 102422 Myotubularin-like phosphatases
9 9 SCOP 56171 Phoshoinositide 3-kinase (PI3K), catalytic domain
9 9 SCOP 63611 Pumilio repeat
9 9 SCOP 74771 Clathrin adaptor core protein
8 8 SCOP 82568 Ubiquitin carboxyl-terminal hydrolase, UCH
7 7 SCOP 50448 Elongation factors
7 7 SCOP 52641 Motor proteins
7 7 SCOP 52800 Dual specificity phosphatase-like
7 7 SCOP 56816 Sec1/munc18-like (SM) proteins
7 7 SCOP 81838 BEACH domain
7 7 SCOP 103033 Hypothetical protein YwqG
6 6 SCOP 47114 Nucleosome core histones
6 6 SCOP 53687 Tryptophan synthase beta subunit-like PLP-dependent enzymes
6 5 SCOP 53766 Oligosaccharide phosphorylase
6 6 SCOP 56205 Hect, E3 ligase catalytic domain
6 6 SCOP 64422 Inositol polyphosphate 5-phosphatase (IPP5)
6 6 SCOP 75521 Clathrin coat assembly domain
6 6 SCOP 160861 Alkylsulfatase-like
5 3 SCOP 47924 Ypt/Rab-GAP domain of gyp1p
5 5 SCOP 49448 Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
5 5 SCOP 52491 Tubulin, GTPase domain
5 5 SCOP 52541 Nucleotide and nucleoside kinases
5 5 SCOP 53402 Cystathionine synthase-like
5 3 SCOP 55946 TATA-box binding protein (TBP), C-terminal domain
5 3 SCOP 55974 S-adenosylmethionine synthetase
5 5 SCOP 56673 DNA polymerase I
5 5 SCOP 63984 Sir2 family of transcriptional regulators
5 5 SCOP 101153 Mob1/phocein
5 5 SCOP 101888 Apyrase
4 4 SCOP 47577 Calponin-homology domain, CH-domain
4 4 SCOP 48399 Phoshoinositide 3-kinase (PI3K) helical domain
4 4 SCOP 50466 EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
4 4 SCOP 50892 Cyclophilin (peptidylprolyl isomerase)
4 2 SCOP 51557 Adenosine/AMP deaminase
4 4 SCOP 51800 Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain
4 4 SCOP 52167 Ribosomal protein L4
4 4 SCOP 52670 RecA protein-like (ATPase-domain)
4 4 SCOP 53168 Purine and uridine phosphorylases
4 4 SCOP 53417 GABA-aminotransferase-like
4 4 SCOP 53775 Glutaminase/Asparaginase
4 4 SCOP 53785 Phosphofructokinase
4 3 SCOP 54981 EF-G/eEF-2 domains III and V
4 4 SCOP 55308 Tubulin, C-terminal domain
4 4 SCOP 56291 ROO N-terminal domain-like
4 4 SCOP 56802 Acetyl-CoA synthetase-like
4 4 SCOP 75633 Cullin homology domain
4 4 SCOP 101448 Formin homology 2 domain (FH2 domain)
4 4 SCOP 110832 Nip7p homolog, N-terminal domain
3 3 SCOP 46566 Chaperone J-domain
3 3 SCOP 47502 Calmodulin-like
3 3 SCOP 47974 Ribosomal protein S7
3 3 SCOP 48360 p120GAP domain-like
3 3 SCOP 48426 Sec7 domain
3 3 SCOP 48446 14-3-3 protein
3 3 SCOP 50114 C-terminal domain of ribosomal protein L2
3 3 SCOP 50136 Alcohol dehydrogenase-like, N-terminal domain
3 3 SCOP 50461 Ribosomal protein L3
3 3 SCOP 51550 beta-N-acetylhexosaminidase catalytic domain
3 3 SCOP 51736 Alcohol dehydrogenase-like, C-terminal domain
3 3 SCOP 51751 Tyrosine-dependent oxidoreductases
3 3 SCOP 51848 LDH N-terminal domain-like
3 3 SCOP 52584 Phosphoribulokinase/pantothenate kinase
3 3 SCOP 52923 Transketolase C-terminal domain-like
3 2 SCOP 53083 Hexokinase
3 3 SCOP 53351 Arginine methyltransferase
3 3 SCOP 53461 UDP-glucose pyrophosphorylase
3 1 SCOP 53739 Phosphoglucomutase, first 3 domains
3 3 SCOP 54193 L15e
3 3 SCOP 54687 Ribosomal protein L10e
3 3 SCOP 54748 Ribosomal L11/L12e N-terminal domain
3 3 SCOP 55348 GAPDH-like
3 3 SCOP 55730 N-acetyl transferase, NAT
3 3 SCOP 56048 Ribosomal protein S8
3 3 SCOP 56328 Lactate & malate dehydrogenases, C-terminal domain
3 3 SCOP 57799 Casein kinase II beta subunit
3 3 SCOP 64485 RNA-polymerase beta
3 3 SCOP 64490 RNA-polymerase beta-prime
3 3 SCOP 69646 Arp2/3 complex subunits
3 3 SCOP 88735 TK-like Pyr module
3 3 SCOP 89125 Nop domain
3 3 SCOP 89724 Macro domain
3 3 SCOP 102463 Peptidyl-tRNA hydrolase II
3 3 SCOP 102492 CAF1-like ribonuclease
3 3 SCOP 103492 Preprotein translocase SecY subunit
2 2 SCOP 48246 Protein prenyltransferases
2 2 SCOP 48385 HEAT repeat
2 2 SCOP 48404 Ankyrin repeat
2 2 SCOP 48440 Protein prenylyltransferase
2 2 SCOP 50183 Sm motif of small nuclear ribonucleoproteins, SNRNP
2 2 SCOP 50194 Ribosomal protein L14
2 2 SCOP 50678 ValRS/IleRS/LeuRS editing domain
2 2 SCOP 51396 FMN-linked oxidoreductases
2 2 SCOP 51431 Aldo-keto reductases (NADP)
2 2 SCOP 51591 Class II FBP aldolase
2 2 SCOP 51629 Pyruvate phosphate dikinase, C-terminal domain
2 2 SCOP 51830 Formate/glycerate dehydrogenases, NAD-domain
2 2 SCOP 51931 GDI-like N domain
2 2 SCOP 52314 Ribosomal protein S2
2 2 SCOP 52468 Deoxyhypusine synthase, DHS
2 2 SCOP 52484 Transhydrogenase domain III (dIII)
2 2 SCOP 52773 Histone deacetylase, HDAC
2 1 SCOP 53089 Glycerol kinase
2 2 SCOP 53099 Ribonuclease H
2 2 SCOP 53204 Bacterial dinuclear zinc exopeptidases
2 2 SCOP 53701 Phosphoglucose isomerase, PGI
2 2 SCOP 53921 Fe-only hydrogenase
2 2 SCOP 54212 Translational machinery components
2 2 SCOP 54399 GDI-like
2 2 SCOP 54535 FKBP immunophilin/proline isomerase
2 2 SCOP 54586 Cdc48 domain 2-like
2 2 SCOP 54815 Prokaryotic type KH domain (KH-domain type II)
2 2 SCOP 55283 Ribosomal protein L5
2 2 SCOP 55294 RPB6
2 2 SCOP 55316 L30e/L7ae ribosomal proteins
2 2 SCOP 55419 Translation initiation factor eIF4e
2 2 SCOP 55505 Neurolysin-like
2 1 SCOP 55748 N-myristoyl transferase, NMT
2 2 SCOP 55762 Cofilin-like
2 2 SCOP 55822 YrdC-like
2 2 SCOP 55875 Heat shock protein 90, HSP90, N-terminal domain
2 2 SCOP 55879 DNA gyrase/MutL, N-terminal domain
2 2 SCOP 55921 Creatinase/aminopeptidase
2 2 SCOP 56085 Pyruvate phosphate dikinase, N-terminal domain
2 2 SCOP 56416 Poly(ADP-ribose) polymerase, C-terminal domain
2 2 SCOP 56575 Serpins
2 2 SCOP 56656 Inositol monophosphatase/fructose-1,6-bisphosphatase-like
2 2 SCOP 56713 Prokaryotic type I DNA topoisomerase
2 2 SCOP 63888 P-domain of calnexin/calreticulin
2 2 SCOP 63979 ATP sulfurylase catalytic domain
2 2 SCOP 69061 Arp2/3 complex 21 kDa subunit ARPC3
2 2 SCOP 81812 Helical domain of Sec23/24
2 2 SCOP 82458 Trunk domain of Sec23/24
2 2 SCOP 82755 C-terminal, gelsolin-like domain of Sec23/24
2 1 SCOP 89572 Biotin dependent carboxylase carboxyltransferase domain
2 2 SCOP 89734 L-sulfolactate dehydrogenase-like
2 2 SCOP 89763 Ubiquitin activating enzymes (UBA)
2 2 SCOP 90097 Capz alpha-1 subunit
2 2 SCOP 90100 Capz beta-1 subunit
2 2 SCOP 102646 CoaB-like
2 2 SCOP 102755 Hsp90 middle domain
2 2 SCOP 103366 Hypothetical protein PH1602
2 2 SCOP 143927 beta-CASP RNA-metabolising hydrolases
2 2 SCOP 158600 MgsA/YrvN C-terminal domain-like
1 1 SCOP 46610 Fe,Mn superoxide dismutase (SOD), N-terminal domain
1 1 SCOP 47324 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
1 1 SCOP 47662 t-snare proteins
1 1 SCOP 47808 5' to 3' exonuclease, C-terminal subdomain
1 1 SCOP 48351 BCR-homology GTPase activation domain (BH-domain)
1 1 SCOP 48372 Armadillo repeat
1 1 SCOP 48390 Clathrin heavy chain proximal leg segment
1 1 SCOP 48393 Clathrin heavy-chain linker domain
1 1 SCOP 48453 Tetratricopeptide repeat (TPR)
1 1 SCOP 48558 L-aspartase/fumarase
1 1 SCOP 50282 Cold shock DNA-binding domain-like
1 1 SCOP 50307 DNA ligase/mRNA capping enzyme postcatalytic domain
1 1 SCOP 50325 Inorganic pyrophosphatase
1 1 SCOP 50719 Gln-tRNA synthetase (GlnRS), C-terminal (anticodon-binding) domain
1 1 SCOP 50990 Clathrin heavy-chain terminal domain
1 1 SCOP 51174 gamma-carbonic anhydrase-like
1 1 SCOP 51191 Type I phosphomannose isomerase
1 1 SCOP 51284 dUTPase-like
1 1 SCOP 51352 Triosephosphate isomerase (TIM)
1 1 SCOP 51372 D-ribulose-5-phosphate 3-epimerase
1 1 SCOP 51420 Alanine racemase-like, N-terminal domain
1 1 SCOP 51427 "Hypothetical" protein ybl036c
1 1 SCOP 51534 Type II chitinase
1 1 SCOP 51570 Class I aldolase
1 1 SCOP 51605 Enolase
1 1 SCOP 51714 tRNA-guanine transglycosylase
1 1 SCOP 51883 Aminoacid dehydrogenase-like, C-terminal domain
1 1 SCOP 51900 CoA-binding domain
1 1 SCOP 51943 FAD/NAD-linked reductases, N-terminal and central domains
1 1 SCOP 52030 GroEL-like chaperone, apical domain
1 1 SCOP 52034 Group II chaperonin (CCT, TRIC), apical domain
1 1 SCOP 52142 Uracil-DNA glycosylase
1 1 SCOP 52211 Succinyl-CoA synthetase domains
1 1 SCOP 52300 S-adenosylhomocystein hydrolase
1 1 SCOP 52397 Adenylyltransferase
1 1 SCOP 52403 N-type ATP pyrophosphatases
1 1 SCOP 52513 NagB-like
1 1 SCOP 52652 Nitrogenase iron protein-like
1 1 SCOP 52769 Arginase-like amidino hydrolases
1 1 SCOP 52805 Higher-molecular-weight phosphotyrosine protein phosphatases
1 1 SCOP 52895 spliceosomal protein U5-15Kd
1 1 SCOP 52931 Pyruvate-ferredoxin oxidoreductase, PFOR, domain II
1 1 SCOP 52973 ITPase (Ham1)
1 1 SCOP 52976 Maf-like
1 1 SCOP 53045 5' to 3' exonuclease catalytic domain
1 1 SCOP 53080 Acetokinase-like
1 1 SCOP 53118 DnaQ-like 3'-5' exonuclease
1 1 SCOP 53143 ERF1/Dom34 middle domain-like
1 1 SCOP 53240 Malic enzyme N-domain
1 1 SCOP 53324 Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
1 1 SCOP 53397 Beta-eliminating lyases
1 1 SCOP 53444 Ornithine decarboxylase major domain
1 1 SCOP 53614 Ribokinase-like
1 1 SCOP 53660 Dimeric isocitrate & isopropylmalate dehydrogenases
1 1 SCOP 53698 double-SIS domain
1 1 SCOP 53721 ALDH-like
1 1 SCOP 53749 Phosphoglycerate kinase
1 1 SCOP 53791 Tetrapyrrole methylase
1 1 SCOP 54040 Calpain large subunit, catalytic domain (domain II)
1 1 SCOP 54054 Adenain-like
1 1 SCOP 54224 DNA gyrase/MutL, second domain
1 1 SCOP 54232 GHMP Kinase, N-terminal domain
1 1 SCOP 54237 Ubiquitin-related
1 1 SCOP 54720 Fe,Mn superoxide dismutase (SOD), C-terminal domain
1 1 SCOP 54827 Enolase N-terminal domain-like
1 1 SCOP 55206 RNA 3'-terminal phosphate cyclase, RPTC
1 1 SCOP 55288 RPB5
1 1 SCOP 55299 YjgF/L-PSP
1 1 SCOP 55323 ERF1/Dom34 C-terminal domain-like
1 1 SCOP 55368 Dihydrodipicolinate reductase-like
1 1 SCOP 55456 SRF-like
1 1 SCOP 55482 N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1
1 1 SCOP 55499 Leishmanolysin
1 1 SCOP 55910 Ribosome anti-association factor eIF6 (aIF6)
1 1 SCOP 55958 Phosphoglucomutase, C-terminal domain
1 1 SCOP 56078 Synapsin C-terminal domain
1 1 SCOP 56092 ATP-dependent DNA ligase catalytic domain
1 1 SCOP 56108 Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta
1 1 SCOP 56220 DNase I-like
1 1 SCOP 56236 Class II glutamine amidotransferases
1 1 SCOP 56720 Type II DNA topoisomerase
1 1 SCOP 56822 Hybrid cluster protein (prismane protein)
1 1 SCOP 57851 RING finger domain, C3HC4
1 1 SCOP 63412 MPP-like
1 1 SCOP 63801 ATP sulfurylase N-terminal domain
1 1 SCOP 63873 Translationally controlled tumor protein TCTP (histamine-releasing factor)
1 1 SCOP 64154 YjeF N-terminal domain-like
1 1 SCOP 64159 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain
1 1 SCOP 69341 C-terminal domain of adenylylcyclase associated protein
1 1 SCOP 69573 Molybdenum cofactor biosynthesis protein MoeB
1 1 SCOP 69746 Pseudouridine synthase II TruB
1 1 SCOP 74911 Aldose 1-epimerase (mutarotase)
1 1 SCOP 75073 Hydantoinase (dihydropyrimidinase), catalytic domain
1 1 SCOP 81380 Skp1 dimerisation domain-like
1 1 SCOP 81656 Meta-cation ATPase, catalytic domain P
1 1 SCOP 82110 MIR domain
1 1 SCOP 82258 SAH/MTA deaminase-like
1 1 SCOP 82267 TatD Mg-dependent DNase-like
1 1 SCOP 82385 phosphatase domain of polynucleotide kinase
1 1 SCOP 82388 Predicted hydrolases Cof
1 1 SCOP 82645 The homologous-pairing domain of Rad52 recombinase
1 1 SCOP 88746 PFOR Pyr module
1 1 SCOP 88760 TK-like PP module
1 1 SCOP 88771 PFOR PP module
1 1 SCOP 88784 rRNA adenine dimethylase-like
1 1 SCOP 88786 C5 cytosine-specific DNA methylase, DCM
1 1 SCOP 89494 HMGL-like
1 1 SCOP 89624 Ribose/Galactose isomerase RpiB/AlsB
1 1 SCOP 89818 Mago nashi protein
1 1 SCOP 89943 eEF1-gamma domain
1 1 SCOP 100888 Lesion bypass DNA polymerase (Y-family), catalytic domain
1 1 SCOP 101279 N-terminal domain of adenylylcyclase associated protein, CAP
1 1 SCOP 101547 ASF1-like
1 1 SCOP 102111 (2r)-phospho-3-sulfolactate synthase ComA
1 1 SCOP 102575 NOL1/NOP2/sun
1 1 SCOP 103507 Mitochondrial carrier
1 1 SCOP 110582 Indigoidine synthase A-like
1 1 SCOP 110739 Glycerate kinase I
1 1 SCOP 110910 Monomeric nicotinate phosphoribosyltransferase C-terminal domain
1 1 SCOP 111233 YfcE-like
1 1 SCOP 117019 ATP-dependent DNA ligase DNA-binding domain
1 1 SCOP 117558 Type II thymidine kinase
1 1 SCOP 118076 TRAPP components
1 1 SCOP 118197 YaeB-like
1 1 SCOP 118204 Vacuolar ATP synthase subunit C
1 1 SCOP 140985 PTPA-like
1 1 SCOP 141436 SSRP1-like
1 1 SCOP 144001 Oxysterol-binding protein
1 1 SCOP 159112 RNB domain-like
1 1 SCOP 159513 EMG1/NEP1-like
1 1 SCOP 159623 Fumble-like
1 1 SCOP 159638 Prp8 beta-finger domain-like
1 1 SCOP 159697 TRM1-like
1 1 SCOP 159720 mannose-1-phosphate guanylyl transferase
1 1 SCOP 159858 Autophagin-like
1 1 SCOP 161204 Zf-UBP

The following families have one or more weak hits: